|
Malignant neoplasm of lung
|
0.060 |
Biomarker
|
disease |
BEFREE |
MiR-563 plays a tumor suppressive role in lung cancer progression via targeting oncogenic LIN28B.
|
31766078 |
2020 |
|
Carcinoma of lung
|
0.060 |
Biomarker
|
disease |
BEFREE |
MiR-563 plays a tumor suppressive role in lung cancer progression via targeting oncogenic LIN28B.
|
31766078 |
2020 |
|
Primary malignant neoplasm of lung
|
0.060 |
Biomarker
|
disease |
BEFREE |
MiR-563 plays a tumor suppressive role in lung cancer progression via targeting oncogenic LIN28B.
|
31766078 |
2020 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The level of miR-563 and LIN28B and their correlation were analyzed in 27 cases of lung tumor tissues by real-time PCR.
|
31766078 |
2020 |
|
Liver carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our data reveal that Lin28B may serve as a predictive biomarker and a treatment target to reverse HCC chemotherapy resistance in future clinical practice.
|
31762817 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
LIN28B/IRS1 axis is targeted by miR-30a-5p and promotes tumor growth in colorectal cancer.
|
31713927 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
LIN28B/IRS1 axis is targeted by miR-30a-5p and promotes tumor growth in colorectal cancer.
|
31713927 |
2019 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of LIN28B in OS13 cells reduced tumorigenesis, decreased chemoresistance, and reversed oxidative phosphorylation function.
|
31705593 |
2020 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
KLK6 overexpression also induced the RNA-binding protein LIN28B and high-mobility group AT-hook 2 (HMGA2) transcription factor, two essential regulators of cell invasion and metastasis.
|
31692974 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Research has revealed that microRNA (miR)‑4500 is downregulated in non‑small cell lung cancer (NSCLC), and miR‑4500 suppresses tumor growth by targeting lin‑28 homolog B and NRAS proto‑oncogene, GTPase.
|
31638206 |
2019 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, in vivo experiments are needed for the application of miR-152/LIN28B axis in the treatment for diabetic retinopathy.
|
31609010 |
2020 |
|
Neuroblastoma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms.
|
31601998 |
2020 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms.
|
31601998 |
2020 |
|
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms.
|
31601998 |
2020 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Notably, downregulation of RPSAP52 impairs the balance between the oncogene LIN28B and the tumor suppressor let-7 family of miRNAs, inhibits cellular proliferation and migration in vitro and slows down tumor growth in vivo.
|
31484926 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, we show that LIN28A and LIN28B are significantly lower and lethal-7 (<i>let-7</i>) microRNAs (miRNAs) significantly higher in term human IUGR <i>vs.</i> normal placentas.
|
31415216 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggested that exosomes derived from local cancer could promote the formation of distant metastases through transferring the exosomal protein Lin28B to the metastatic cancer cells.
|
31413760 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggested that exosomes derived from local cancer could promote the formation of distant metastases through transferring the exosomal protein Lin28B to the metastatic cancer cells.
|
31413760 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Considering the similarities between cancer and trophoblast cells, we hypothesize that LIN28B also is necessary for the presence of AR in human trophoblast cells.
|
31215730 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Considering the similarities between cancer and trophoblast cells, we hypothesize that LIN28B also is necessary for the presence of AR in human trophoblast cells.
|
31215730 |
2019 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Analysis of LIN28B and HMGA2 expression levels in cohorts from The Cancer Genome Atlas sarcoma dataset revealed a strong inverse-relationship between elevated expression and overall survival (OS) in 260 patients (p = 0.005) and disease-free survival (DFS) in 231 patients (p = 0.02), suggesting LIN28B and HMGA2 are important regulators of sarcoma biology.
|
31147574 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Analysis of LIN28B and HMGA2 expression levels in cohorts from The Cancer Genome Atlas sarcoma dataset revealed a strong inverse-relationship between elevated expression and overall survival (OS) in 260 patients (p = 0.005) and disease-free survival (DFS) in 231 patients (p = 0.02), suggesting LIN28B and HMGA2 are important regulators of sarcoma biology.
|
31147574 |
2019 |
|
Sarcoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Our results highlight an important role for the LIN28B/LET-7 axis in human sarcoma pathogenesis and suggest that the therapeutic targeting of LIN28B may be relevant for patients with sarcoma.
|
31147574 |
2019 |